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I was looking into taking CBD to help with all this stuff. Does anyone take CBD oil while on blood thinners or know if this is safe? I am going to ask my doctor soon but i have a feeling he will not really know about CBD and the risks of doing this.
Using Medical Marijuana with Blood Thinners.. It’s advisable that the oil blend should be high THC and high CBD (2 ounces of THC to 1 ounce of CBD). Patients should avoid the use of oil and omega-3 fatty acid supplements without coordinating with your physician. The oils may increase the.
For those taking Warfarin (coumadin) or another blood thinner, this may prolong the effect of your dose and temporarily increase the thinning of your blood, as CBD increases the level of the drug in your blood.
In relation to the P450 enzyme, taking CBD with warfarin may cause the warfarin to increase its potency, as CBD and warfarin use the same internal pathways to take effect within the liver. This could potentially cause unhealthy INR levels.
CBD reduces the enzymatic degradation of Warfarin, thereby increasing its duration of action and effect. A person taking a CBD-rich product should pay close attention to changes in blood levels of Warfarin, and adjust dosage accordingly as instructed by their doctor and pharmacist.
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In addition, CBD can interact with warfarin and increase the risk of bleeding complications. CBD is metabolized through the hepatic P450 enzyme system, which warfarin also uses. Both share the same isoforms in their metabolism (CBD acts on CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 and warfarin acts on five of them).
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Cbd oil deactivates the enzyme in your liver responsible for metabolizing many drugs, including warfarin. You could have a high INR and a high chance of internal bleeding. You could have a high INR and a high chance of internal bleeding.